Exosome application means applying the preparation to the skin immediately after a procedure that temporarily makes the skin barrier more permeable — microneedling (dermapen, RF), fractional laser or peeling. This is the main form of exosome use in aesthetics: the lyophilised concentrate is reconstituted just before use and spread over the prepared area, with the procedure finished off with a hydrogel or sheet mask. For application the catalogue offers Nithya Exodora Dermal and Hair Complex, Petaran Poly Exocomplex, and ready-made masks with exosomes. Application is often included in a combined protocol with polynucleotides or collagen: those work on skin structure, exosomes on cell signalling.